Blister strip

ABSTRACT

A blister strip which can be stuck onto the skin, is formed from at least two sheets and has an applicator for applying a medium contained in the blister to the skin, wherein the blister strip includes an upper sheet, with at least one protuberance, wherein the underside of the upper sheet, the underside enclosing the protuberance, is of adhesive configuration. The blister strip has a lower sheet, which covers the lower surface of the blister strip and can be drawn off from the adhesive underside of the upper sheet. The protuberance contains an applicator, separating the protuberance into at least two sub-volumes. Wherein the applicator has at least one opening, which connects two sub-volumes, wherein one sub-volume is located between the applicator and the lower sheet, and wherein at least one sub-volume is entirely surrounded by the inner surface of the protuberance and the applicator, and contains the medium.

The invention relates to a blister strip for sticking onto the skin, inparticular for carrying out an allergy test.

A blister strip is a laminar structure which comprises at least twolayers, wherein one or more cavities are located between the layers, thecavities being referred to as blisters. Blister strips are known, forexample, as drug packaging, wherein active substances are contained inthe blisters in the form of pills which can be pressed out of theblister. A blister strip here consists of two films, wherein the lowerfilm is flat and the upper film has dome-shaped, dimensionally stableprotuberances (bulges, blisters), and therefore cavities are formedbetween the films. By application of pressure onto the dome of the upperfilm, the lower film is torn off and the contents of the cavity emerge.

In order to carry out an allergy test, test strips are known which canbe applied to the skin and contain an allergen in a capsule or a cavity,said allergen generally being present in a liquid or gel-like carriersubstance. In these allergy tests, the allergen can be brought intocontact with the skin by opening or destroying the capsule or cavity. Itis known according to the prior art to design said allergy test stripsas blister strips. According to the prior art, blister strips are alsoknown which can be stuck onto the skin of the person to be tested.

In the case of the blister strips which can be stuck on and containliquid allergens, it is known to produce said blister strips inaccordance with the above-described drug packaging design. During use,the lower film is stuck onto the skin. An applicator is attached to theinner side of the dome of the upper film, said applicator being capableof piercing the lower film and optionally also of slightly penetratingthe skin. The dome is at least partially filled with liquid, wherein thelatter emerges through the hole in the film and is thus intended to passonto or into the skin. Blister strips according to this principle areshown, for example, in WO 8705200 A1 and US 2014276196 A1. Adisadvantage of this design is that the film has to pierced with theapplicator, which may have the consequence of an irregular or unreliabledischarge of the allergen, or entails the risk of parts of the filmpenetrating the skin. It is disadvantageous that this design permitsonly a virtually punctiform introduction of the allergen, and the liquidmay pass between skin and film, with the risk of mixing.

In the case of other blister strips which can be stuck on, it is knownto provide the allergen as a gel, or to keep the allergen in liquid inan absorbent substrate, or to keep the liquid on the inner side of theblister by means of surface tension. Blister strips with this principleare shown, for example, in U.S. Pat. No. 4,802,493A, U.S. Pat. No.4,966,159A and US2007276284A1. In this case, the lower film can beremoved prior to the application of the blister strip, without liquidemerging. An applicator can again be present on the inner side of thedome of the upper film, with which applicator the skin can be injured toa small extent. It is disadvantageous that the allergen has to bepresent in an absorbent substrate or as a gel, and there is also therisk that, during handling after the film has been pulled off, theallergen is applied at a wrong location or the gel or the absorbentsubstrate is contaminated with other allergens (for example from otherblisters).

U.S. Pat. No. 5,099,857 A furthermore indicates providing an additionalcapsule in the blister below the applicator, said capsule beingdestroyed in order to release the test liquid.

The object on which the invention is based consists in providing ablister strip for allergy tests, which blister strip can be stuck on,has a simple design and permits the use of liquid test substances,wherein an applicator is intended to be attached in the blister, saidapplicator permitting a controlled slight injury of the skin, whereinthe intention is for no film to be pierced during the use of theapplicator.

To achieve the object, it is proposed to design the applicator and toarrange the same in the blister in such a manner that said applicatorseparates the blister into two regions. The first region lies betweenthe inner side of the preferably dome-shaped protuberance of the upperfilm and the applicator and is consequently referred to as a liquidreservoir. The second region lies between the applicator and the lowerfilm and is consequently referred to as the squeezing-out reservoir. Bymeans of the applicator, the two regions are separated from each otherin a sealed manner in the unopened state of the blister strip.

In order to apply the blister strip, the lower film is pulled off fromthe strip, thus exposing the lower side of the upper film, which isprovided with a skin-compatible adhesive at least in the region aroundeach blister. The lower side of the upper film is now stuck onto theskin, and therefore the squeezing-out reservoir is now formed by theapplicator, optionally by the side walls of the protuberance below theapplicator, and the skin. By exertion of a force on the dome of theblister, the liquid of the liquid reservoir is moved through an openingin the applicator into the squeezing-out reservoir.

If, after the liquid reservoir is squeezed out, the force on theapplicator is increased somewhat further, said applicator is moved inthe direction of the skin, and, for example, by finger pressure andcareful circulating massaging movement of the applicator, the skin canbe superficially injured in the form of scratches and the allergenliquid can penetrate into the uppermost skin layers.

The action of force is subsequently removed and the blister strip isleft for some minutes on the skin in order to wait for a reaction of thebody to the allergen before the blister strip is pulled off.

The invention is illustrated with reference to drawings:

FIG. 1: shows, in a sectional view, the design of an exemplary blisterstrip according to the invention.

FIG. 2: shows, in a sectional view, an exemplary blister strip accordingto the invention after removal of the lower film.

FIG. 3: shows, in a sectional view, an exemplary blister strip accordingto the invention which is stuck onto the skin, with a blister applicatorin the starting state and with an applicator which has already beenpressed in and in which the allergen liquid has thus been squeezed outinto the squeezing-out reservoir.

FIG. 4: shows, in a sectional view, an exemplary blister strip accordingto the invention which is stuck onto the skin, with a pressure-actuatedapplicator and skin penetration which has taken place.

FIG. 5: shows, in a sectional view, an exemplary blister strip accordingto the invention with alternative configurations.

FIG. 6: shows an exemplary blister strip according to the invention fromabove.

FIG. 7: FIGS. 7a to 7d show, in a sectional view, an exemplary blisterstrip according to the invention in a plurality of steps of an exemplaryproduction process.

FIG. 8: FIGS. 8a to 8c show exemplary applicator points according to theinvention.

Insofar as the direction indications at the top and at the bottom orupper and lower are used in the description of the figures, this refersto the position of the blister strip in alignment with the surface towhich the strip is applied as intended during the application. At thebottom or the lower side is therefore the side which lies facing saidsurface.

FIG. 1 shows the design of a preferred blister strip according to theinvention, wherein two blisters are shown in cross section, wherein eachblister is formed by a protuberance 2.1 of the upper film 2, which, asis illustrated, preferably has a dome shape. An applicator 1 is attachedinside each blister and is adhesively bonded on the annular contactsurface to the inner side of the protuberance 2.1, or is compressed withsaid inner side in a liquid-tight manner. The protuberance 2.1 is thusdivided into two regions by the applicator 1. The applicator 1 has anopening 1.2 through which liquid can pass during the application of theblister strip.

The two regions are separated from each other in a sealed manner in theunopened state of the blister strip, which can be achieved, for example,by a sealing stopper 4 which is connected by adhesive bonding to thelower film 3 and can thus be removed with the latter. This sealingstopper 4 can close, for example, only the opening 1.2, or, asillustrated in the left blister, the entire area of the blister. Thisembodiment has the advantage that the sealing stopper 4 can easily beinserted mechanically and, during the manufacturing of the blisterstrip, no adhesive can pass into the blister or onto the applicatorpoint 1.1.

The applicator 1 preferably has a disc shape, wherein the edge of thedisc is somewhat wider and projects downward from the disc in order toincrease the contact surface with the protuberance 2.1.

The applicator point 1.1 likewise protrudes downward centrally from theapplicator 1, wherein the applicator point 1.1 preferably protrudesfurther downward than the edge of the disc, and therefore, when theapplicator 1 is pressed downward, said applicator point comes intocontact with the skin before the edge of the disc; otherwise, theapplicator 1 itself would have to be somewhat deformable, preferablyelastically deformable, such that its center and therefore theapplicator point 1.1 could be moved somewhat downward when the edge ofthe disc is already in contact with the skin 7. The disc is preferablyinserted in such a manner that, below the disc, the dome walls of theprotuberance 2.1 form a boundary of the squeezing-out reservoir 6, i.e.the lower end of the edge of the disc is inserted into the protuberance2.1 spaced apart from the lower side 2.2 of the film 2. If theprotuberance 2.1 has a dome shape, the surface with which the disc liesagainst the protuberance 2.1 is preferably matched to the shape of thedome, i.e. is designed to be annular and in a manner tapering upward,and therefore the disc is approximately a conical disc or sphericaldisc.

The applicator point 1.1 is that part of the applicator 1 which can bebrought into contact with the skin 7 in order to be able to cause aslight lesion of the latter. The applicator point 1.1 here has one ormore sharp or pointed elements or edges with which the skin 7 can bescratched or scored or penetrated in a punctiform manner. The applicatorpoint 1.1 here can be a hollow needle point or pricking needle point orcan have a plurality of said points, or, similarly to sandpaper, canhave a plurality of geometries projecting regularly or irregularly fromthe surface. The sharp or pointed elements are preferably attachedannularly around the opening 1.2 of the applicator 1, the openingpreferably running centrally in the applicator point 1.1. If theapplicator point 1.1 is a hollow needle, the opening of the hollowneedle can be the opening 1.2 of the applicator 1.

Three exemplary, particularly preferred applicator points 1.1 accordingto the invention are shown in FIGS. 8a, 8b, 8c . The applicator pointaccording to the invention has been invented specifically for thisapplication, but, because of the advantageous configuration, saidapplicator point can also be used for other applications, for examplefor the advantageous improvement of known (allergy test) applicators.The applicator point 1.1 according to the invention has at least onepreferably central opening 1.2, and is designed, for example, as acylinder. On the side facing the skin 7 or the lower film 3, theapplicator point 1.1 has a plurality of sharp or pointed elements whichare preferably arranged annularly around the opening 1.2. Said elementsare particularly advantageously formed by hollow needle points which canreceive a small quantity of liquid during the application and canintroduce said liquid into the skin 7, or, after penetration of theuppermost skin layers, can introduce it in a delayed manner by contactwith the allergen liquid. As shown in FIG. 8a , conventional, obliquelytrimmed hollow needles can be used as the pointed elements, wherein saidhollow needles can penetrate into the skin to the extent that theyprotrude out of the applicator point 1.1.

Preferably, the hollow or penetrator needles are not offset obliquely,but rather horizontally, as shown in FIGS. 8b and 8c , in order to avoiddeep penetration and therefore actually only to penetrate the uppermostskin layer. The shape of the penetrator needle point here isparticularly preferably formed concavely, in the shape of a trough, andcan also be provided with a very fine toothing on the periphery.

As shown in FIG. 8c , the applicator point 1.1 itself can preferably beformed in a trough-shaped or concave manner on the lower side, andtherefore a greater quantity of liquid can remain in the region betweenthe pointed or sharp elements. This can be achieved, for example, by thefact that the small opening 1.2 at the lower end has a phase, roundedportion or depression in order to increase the diameter thereof. Theapplicator point 1.1 is preferably manufactured by injection molding,wherein preferably also the pointed or sharp elements and/or theapplicator 1 are formed in the injection mold, and therefore anapplicator 1 which is finished ready for use is manufactured in oneworking step. If the pointed or sharp elements are composed of adifferent material than the applicator point 1.1, said elements arepreferably inserted into the injection mold such that they can bepartially embedded into the material of the applicator point during theinjection molding. As illustrated in FIG. 2, the lower film 3 can bepulled off, wherein the upper surface 3.1 of the lower film 3, whichsurface lies against the lower side 2.2 of the upper film 2, is designedas an adhesive protective film. So that the sealing stopper 4 adhere tothe lower film 3, it is possible for the lower film 3 not to be designedas an adhesive protective film in the region of the sealing stopper 4.By pulling off the lower film 3 with the sealing stopper 4, the adhesivelower side 2.2 of the upper film 2 and the opening 1.2 of the applicator1 are exposed. The liquid does not pass through the opening 1.2, as longas no pressure is exerted on the protuberance 2.1, since no air canpenetrate into the liquid reservoir 5 through the small opening 1.2.

The sealing stopper 4 therefore serves, during the storage or handlingof the unopened blister strip, to prevent the liquid reservoir 5 frombeing emptied into the squeezing-out reservoir 6 by unintentionalcompression of the protuberance 2.1.

As illustrated in FIG. 3, the opened blister strip is stuck with theadhesive lower side 2.2 of the upper film 2 onto the skin 7, as a resultof which a cavity which is sealed off from the surroundings is formedbetween applicator 1 and the skin 6 in the form of the squeezing-outreservoir 6. As can be seen in the second blister of FIG. 3, bycompression of the protuberance 2.1 the volume of the liquid reservoir 5can be reduced, as a result of which the liquid is pressed through theopening 1.2 of the applicator 1 and passes into the squeezing-outreservoir 6.

As illustrated in the second blister in FIG. 4, by further compressionof the protuberance 2.1, the applicator 1 can be brought into contactwith the skin 7. This takes place if the inner side of the protuberance2.1 lies against the applicator 1, or if the resistance of the liquid tosqueezing out is higher than the resistance of the dome side walls,which laterally bound the squeezing-out reservoir 6 below the applicator1, to deformation.

Owing to the dome geometry, the compression of the upper flat dome capwhich bounds the liquid reservoir 5 requires less force than thecompression of the steep dome side walls below the applicator 1.

If the applicator point 1.1 is in contact with the skin 7, the allergencan be introduced into the skin 7 by slightly circling massaging of theblister. For this purpose, the sharp or pointed elements of theapplicator point 1.1 penetrate somewhat into the skin 7. By suitableconfiguration of the applicator point 1.1, for example by the distancewith which the sharp or pointed elements protrude out of the applicatorpoint 1.1, it can be determined how deep or into which skin layer theallergens penetrate. The present design is also advantageous if theapplicator 1 does not have any pointed or sharp elements, for examplefor carrying out epicutaneous tests.

Depending on the size of the blister or depending on the quantity ofliquid in the liquid reservoir 5, it may be necessary to provide anoption in order to allow the air enclosed in the squeezing-out reservoir6 to escape so that said air is not pressed under the adhesive layer ofthe film 2 with an inadvertent and uncontrolled escape of liquidpossibly taking place as a result. One option is to provide apredetermined breaking point so that liquid can only escape laterallyunder the adhesive layer and therefore passes into the surroundings andnot into another blister. A further option would be to connect thesqueezing-out reservoir 6 to an expandable volume, for example to asecond, empty, compressed blister, or to a further, separated volumewhich lies between the protuberance 2.1 and the applicator 1 and iscompressed in the starting state.

If the blister has a very small surface in comparison to the adhesivesurface (or the distance between two blisters is sufficiently large), orthe volume of the liquid reservoir 5 is small in comparison to thevolume of the squeezing-out reservoir 6, the provision of an air outletcan be omitted.

The volume of the liquid reservoir 5 is preferably circa one fifth ofthe volume of the squeezing-out reservoir 6. The volume of the liquidreservoir 5 is preferably between 20 and 30 μl. In this case, theprovision of an air outlet is not necessary since the small change involume of the squeezing-out reservoir 6 by introduction of the liquid iscompensated for by the elastic flexibility of the skin 7. During theapplication, by moving the point 1.1 onto the skin 8, the volume of thesqueezing-out reservoir 6 is also somewhat reduced, or the smallpositive pressure in the squeezing-out reservoir 6 is somewhatincreased, which leads to a further curvature of the skin 7. Since theallergy test is customarily carried out on the forearm or on the back ofthe horizontal patient, a small trough in which the liquid collects thusarises in the skin 7 in the center of the blister.

As an option for compensating for the additional volume from the liquidreservoir 5 or for the volume of the squeezing-out reservoir 6, which isreduced by pressing down the applicator 1, the adhesive application onthe lower side 2.2 of the upper film 2 can take place somewhat spacedapart from the blister, as shown in FIG. 5. In this case, the adhesiveapplication is formed by a double-sided adhesive film 2.3. Asillustrated in FIG. 5, the blister strip can have an additionalprotective layer 8 which rests on or is fastened to the upper surface ofthe upper film 2. Said protective layer 8 which is preferably formedfrom cardboard or foamed plastic has recesses for the blisters andprotects the blisters from damage during storage or while being stuckonto the skin 7. The application is not obstructed by the protectivelayer 8 since the blister is accessible through the opening in theprotective layer 8. It is also shown in FIG. 5 that the lower film 3 canalso be thermoformed in the region of the blister, and therefore saidfilm itself forms the sealing stopper 4 or closes the opening 1.2 and/orthe entire area of the blister.

A dimensionally stable material, such as hard plastic, in particulartransparent hard plastic, is suitable as material for the applicator 1.The applicator 1 is particularly preferably manufacturedcost-effectively by injection molding. The sharp or pointed elements ofthe applicator point 1.1 can likewise be composed of hard plastic andconnected monolithically to the applicator 1. The sharp or pointedelements can also be composed of metal, glass or another hard,sharp-edged material.

The upper film 2 or lower film 3 can be a plastics film or aluminum foil(in particular hard aluminum foil), or a laminate, i.e. a laminarstructure consisting of a plurality of films. The upper film 2 or theprotuberance 2.1 can preferably be formed transparently. The upper film2 or the material of the protuberance 2.1 is plastically deformable heresuch that, after removal of the compressive force from the protuberance2.1, the latter remains in the deformed state. In the case of an elasticprotuberance 2.1, after removal of the force, the latter would returnagain into its starting shape and would thus partially suck the liquidback from the squeezing-out reservoir 6 into the liquid reservoir 5,which would possibly even be desirable for some applications. In thecase of the side walls of the protuberance 2.1, which are located belowthe applicator 1, an elastic deformation back may be desirable so that,after the application has taken place, the applicator point 1.1 is movedaway somewhat from the skin 7 and therefore the sharp or pointedelements are not in contact with the skin 7 throughout the entire testtime. The same can be achieved in the case of plastically deformableside walls if, after the application, by pulling on the applicator 1 thelatter is moved away somewhat from the skin 7.

The production of a blister strip, as illustrated in FIGS. 7a-7d , cantake place in the following steps:

-   -   Stamping (or thermoforming, etc.) the upper film 2, as a result        of which the latter is permanently deformed in order to form the        blisters.    -   As shown in FIG. 7a , the liquid is passed into the blister, the        upper film 2 here faces with the lower side upward, and        therefore the blister forms a trough.    -   As shown in FIG. 7b , the applicator 1 is inserted into the        blisters.    -   As shown in FIG. 7c , the opening 2.1 or the blister is closed        with the sealing stopper 4. Alternatively, the applicator 1 and        the sealing stopper 4 can be jointly inserted.    -   As shown in FIG. 7d , the blister strip is provided with the        lower film 3 which covers the sealing stopper 4 and the upper        film 2.    -   As furthermore shown in FIG. 7d , the upper film 2 is connected        to the annular lateral surface of the applicator 1.1, for        example by said film being pressed against the applicator 1, for        which purpose, as illustrated, the lateral surface of the        applicator 1 can have a groove or another surface structure (for        example a plurality of indentations or a plurality of vertically        and/or horizontally running grooves) such that the upper film 2        is connected in a form-fitting manner to the applicator 1        (without adhesive bonding or welding). Alternatively, the upper        film 2 can be welded to the applicator 1 by brief action of heat        and pressure. The upper film 2 can be connected to the        applicator 1 at any time after insertion of the applicator 1.

In order to releasably adhesively bond the lower film 3 to the upperfilm 2, the upper film 2 can already be provided with an adhesive layerprior to the introduction of the liquid, or, for example, only after thesealing stopper 4 has been inserted. The sealing stopper 4 can likewisealready have an adhesive layer or at least one punctiform adhesiveapplication before the insertion, or else can be provided therewithafter the insertion. The adhesive layer of the sealing stopper 4preferably has a different composition than the adhesive layer of theupper film 2, and therefore the adhesive layer of the sealing stopper 4strongly adheres to the adhesive protective layer of the lower film 3.Alternatively, the adhesive layer can be applied together with the lowerfilm 3 by the latter being connected in the region of the lower side 2.2of the upper film 2 to the adhesive layer in a slightly adhesive andtherefore releasable manner. In the region of the sealing stopper 4, thelower film 2 adheres strongly and is therefore connected non-releasablyto an adhesive layer.

The provision of the lower side 2.2 of the film 2 and of the lower sideof the stopper 4 with adhesive takes place, for example, by coating orsticking on a double-sided adhesive film. The double-sided adhesive filmhere is highly adhesive in the direction of the upper film 2, isskin-compatible in the direction of the skin and is adhesive to anextent such that the test can be carried out without causing a greatamount of pain as the adhesive film is being pulled off.

Alternatively to the described method, the liquid can be injectedthrough the opening 1.2 of the applicator 1 after said applicator hasbeen inserted into the blister and adhesively bonded to the blister. Theapplicator in this case preferably has at least two opening 1.2, andtherefore air can escape through the second opening during the filling.

After application of the lower film 3, the blisters and the applicators1 arranged therein are packaged in a sterile manner and protectedagainst contamination. An advantage of the present design of the blisterstrip is that the latter is to be opened only immediately prior toapplication and an additional instrument does not have to be used. Theallergy test strip is therefore storable and transportable and can beused by untrained staff and even in hygienically dubious ambientconditions without there being an increased risk of infection for theperson being investigated or for the applier.

Since, owing to the simple design, the allergy test strip can beproduced in an advantageous manner in mass production and is extremelysimple and safe to apply, it is excellently suited for rapid allergytests with little expenditure of time for professionals or forself-application.

The blister strip has at least one allergen-containing blister. Inaddition, a blister can be present which contains the liquid without anallergen, in order to carry out the negative control, and/or a blisterwith histamine in order to carry out the positive control.

In addition, any desired number of further blisters can be present,wherein each contains an allergen to be tested. The blister strip canhave one row of blisters, or two or more parallel rows of blisters. Theblister strip preferably has a row with 8 blisters. For example, aperson can thus be tested for 14 allergens (including a positive and anegative test) with two differently loaded blister strips, withapplication of one strip each on the inner side of each forearm. Theloading of the blister strips can be adapted to the respective area ofuse (for example geographically, or investigation of individual allergengroups, for example animals/trees/grasses . . . ).

The blister strip can be combined with an adhesive strip which, afterthe blister strip is pulled off, remains on the skin and bears therespective identification of the substance contained in the blister, asshown in FIG. 6. The identification can also be attached to the blisterstrip itself and transferred, for example, manually. A furtherallocation possibility would be to arrange two or more blisters at acharacteristic distance from one another so that, from the position ofthe, for example, increased distance, the position of the blister stripon the skin after being pulled off can be reconstructed, or a templatecan be applied only in one way and therefore unambiguously. A furtherpossibility would be to arrange one more blisters offset from the otherblisters arranged in a row.

Reference will also be made by way of example and in no way definitivelyto the following possible generalizations in relation to the preferredconfiguration of the invention depicted in the description of thefigures, which generalizations are intended according to the inventionto be covered by the present scope of protection.

The blister or the protrusion of the upper film can have a shapediffering from the dome, for example can be cylindrical or rectangular,or can have a complex volume which consists, for example, of a cavitywith two or more domes.

Instead of the sealing stopper 4 or in addition, the applicator 1 canhave a thin membrane which closes the opening 1.2 and tears whenpressure is exerted.

It is also conceivable for the applicator to separate the blister intothree or more partial regions which are sealed in relation to oneanother, and a connection is opened only during the application. Forexample, the allergen or an active substance can thus be present as asolid in one partial region and can be dissolved in the liquid fromanother partial region only directly during the application. The mediumcontained in the first partial region, i.e. in the liquid reservoir 5,can be, in addition to liquid, also a gel, grease or Vaseline.

1. A blister strip which can be stuck onto the skin and is formed fromat least two films and has an applicator for applying a medium containedin the blister and the substances contained in the medium onto or intothe skin, wherein the blister strip comprises an upper film which has atleast one protuberance, wherein the lower side of the upper film, whichlower side surrounds the protuberance, is designed so as to be adhesive,and the blister strip has a lower film which covers the lower surface ofthe blister strip and can be pulled off from the adhesive lower side ofthe upper film, wherein an applicator is inserted in the protuberance ofthe upper film, said applicator separating the protuberance into atleast two partial volumes, the applicator has at least one opening whichconnects two partial volumes, one partial volume lies between theapplicator and the lower film, and at least one partial volume isentirely enclosed by the inner surface of the protuberance and theapplicator and contains the medium.
 2. The blister strip as claimed inclaim 1, wherein at least one of the films is a laminate.
 3. The blisterstrip as claimed in claim 1, wherein the protuberance is a dome.
 4. Theblister strip as claimed in, claim 1, wherein the applicator has atleast one pointed or sharp element which can be brought into contactwith the skin.
 5. The blister strip as claimed in claim 1, wherein thelower film has a sealing stopper which closes the opening of theapplicator.
 6. The blister strip as claimed in claim 5, wherein thesealing stopper adhesively bonded, to the lower film, or is formed by aprotuberance of the lower film.
 7. The blister strip as claimed in claim5, wherein the sealing stopper closes the entire area of theprotuberance of the upper film.
 8. The blister strip as claimed in claim1, wherein the applicator is disk-shaped and is connected all the wayaround at the edge of the disk to the inner wall of the protuberance,wherein, in the center of the disk, the applicator has an applicatorpoint which projects from the disk in the direction of the lower film,wherein, in the applicator point, at least one opening runs through theapplicator.
 9. The blister strip as claimed in claim 8, wherein theapplicator point has one or more central openings, wherein, annularlyaround the opening, sharp or pointed elements point from the applicatorpoint in the direction of the lower film or the skin.
 10. The blisterstrip as claimed in claim 4, wherein at least one sharp or pointedelement is a hollow needle.
 11. The blister strip as claimed in claim 1,wherein the applicator is adhesively bonded or welded to or compressedwith the upper film.
 12. The blister strip as claimed in claim 1,wherein the edge of the applicator has a structured design, and theupper film is pressed in a form-fitting manner into said structure. 13.The blister strip as claimed in claim 8, wherein the edge region of thedisk of the applicator is designed to be wider than the region of thedisk between the edge and the applicator point.
 14. The blister strip asclaimed in claim 8, wherein the applicator is inserted into theprotuberance in such a manner that the lower edge of the disk liesspaced apart from the adhesive lower side of the upper film.
 15. Theblister strip as claimed in claim 1, wherein the upper film is composedof a plastically deformable material.
 16. The blister strip as claimedin claim 1, wherein the applicator is a dimensionally stable body and isformed from hard plastic.
 17. The blister strip as claimed in claim 1,wherein a venting opening is present in that partial volume of theprotuberance which does not contain the medium, wherein the ventingopening leads into the surroundings and is closeable, or opens into asealed expandable volume.
 18. The blister strip as claimed in claim 1,wherein the medium is a liquid.
 19. The blister strip as claimed inclaim 1, wherein the medium contains an allergen.
 20. The blister stripas claimed in claim 19, wherein the blister strip has a plurality ofblisters, wherein each blister contains a medium, wherein one onlycontains the medium, one additionally contains histamine, and there areany desired number of blisters with distinguishable allergens.